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Myrcene and its effects

Cannabis’s distinct aroma doesn’t arrive from your favorite cannabinoids. Instead, it’s the terpenes that give cannabis its distinct fragrance and flavor. They may also affect the cannabis experience and may convey some of its potential therapeutic benefits.


One of the most familiar terpenes found in cannabis is myrcene. Beyond cannabis, myrcene is found in hops and is the reason for the peppery, spicy, balsam fragrance in beer. It’s also been applied in lemongrass, which has been used in traditional folk medicine for centuries.


How common is myrcene in cannabis?


Myrcene is the most commonly found terpene in modern commercial cannabis. When we look at thousands of samples tested by Leafly lab partners, we see this clearly. On average, myrcene represents over 20% of the terpene profile in current commercial strains, although individual samples vary widely in their terpene content.


Myrcene also happens to be the most likely cannabis terpene that is dominant in flower. A strain’s “dominant” terpene is simply the terpene present at the highest level. In modern commercial cannabis, only a limited number of terpenes show up as dominant even though there are many more cannabis terpenes in a strain’s overall profile.


If you randomly picked a flower product off of a shelf in a legal state, you could expect it to be myrcene-dominant about 40% of the time. This reflects the relative absence of chemical diversity in modern commercial cannabis. There’s still room for breeders to experiment with increasing the chemical diversity of strains, potentially even creating novel strains with terpene profiles that are unlike anything commercially available today.


High-myrcene cannabis strains


What popular strain names end up being associated with the highest levels of myrcene? The following prolific strains tend to produce high levels of myrcene:

OG Kush

Blue Dream

Remedy

9 Pound Hammer

Grape Ape

FPOG

Granddaddy Purple

Tangie

Harlequin


Strain names commonly classified as indica, sativa, or hybrid usually contain high levels of myrcene, including popular sativa-dominant hybrids like Tangie and Blue Dream. You’ll also notice that myrcene is common in both THC and CBD strains alike.


Myrcene levels in indica and sativa strains

It is usually said that whether a strain will have “indica” or “sativa” effect can be known by its myrcene levels. Claims have been made that strains with more than 0.5% myrcene by weight will produce “indica” (relaxing) effects, while strains <0.5% myrcene by weight will produce “sativa” (energizing) effects. If this claim was true, we would see a clear difference in myrcene levels between strains labeled as indica, hybrid, and sativa. Indicas should have mostly >0.5% myrcene, sativas should have mostly <0.5%, and hybrids should be in the middle.


When we use lab data to look at myrcene levels across strain names based on their popular indica, hybrid, and sativa designations, the results do not agree with the claims:

Generally, flower products tend to have similar myrcene levels across indicas, hybrids, and sativas. There is also no clear indication from the data to support a strict rule like, “more than 0.5% myrcene = indica.”


This claim may have originated from the common belief that myrcene is sedating and may be responsible for the “couch lock” effect many consumers sometimes feel with cannabis consumption. But do we know that this is actually true? What’s the evidence that myrcene produces sedating effects in humans?


Does myrcene make you sleepy?


Herbal medicines containing myrcene have a long history of being used as a sleep aid in folk medicine. In Mexico, myrcene-rich lemongrass-infused tea has been used in as a sedative and muscle relaxant. It is common for Germans, who are the second-largest hops growers in the world (the US is first), to use myrcene-rich hops preparations as a sleep aid.


However, it’s not clear that any controlled studies have pinpointed myrcene as having a causal role in driving sleep in humans; we are not aware of any well-controlled human clinical trials that clearly demonstrate a sedative effect of myrcene.


More research is also needed to support myrcene’s potential anti-inflammatory effects. Evidence for myrcene’s role in reducing inflammation comes mainly from animal studies.


Other potential benefits of myrcene


Myrcene can block the cancer-causing effects of aflatoxins that are produced by fungi but find their way to our food. These anti-mutagen properties stem from myrcene’s inhibition of the liver enzyme, CYP2B1, which induces aflatoxin’s ability to damage our DNA. Myrcene also protects against DNA damage from toxins such as t-butyl-hydroperoxide. These anti-mutagen effects are consistent with those of other terpenes, along with their antioxidant and antimicrobial benefits.


What’s next for myrcene research?


As for research on other cannabis terpenes, one of the biggest questions regarding myrcene is whether we’re consuming sufficient myrcene doses to achieve these effects. Mouse studies inject between 2mg/kg and 1g/kg (consider that the average adult male weighs around 80 kg) and it’s unclear how much is needed to achieve a therapeutic effect in humans or whether these amounts are present in cannabis strains.


The importance of terpenes in cannabis’ effects are just beginning to become widely appreciated. Research has lagged as scientists have spent the bulk of their effort on the cannabinoids, mostly in isolation. However, that appears to be changing.


The National Institute of Health, which is the largest science funding agency in the country, recently issued a call for proposals to study the analgesic effects of terpenes and “minor cannabinoids” from cannabis. Now if scientists can only get research access to the wide variety of available strains!

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